One-Carbon Metabolism and Neuroplasticity

This hub page exists because multiple articles link here by this capitalized root slug. The in-depth article lives at one-carbon-metabolism-and-neuroplasticity in the PHGDH research folder.

See the full article: One-Carbon Metabolism and Neuroplasticity →

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Background

One-carbon (1C) metabolism couples folate cycling, methionine/SAM chemistry, and serine/glycine interconversion. Its outputs — methyl donors, purine/pyrimidine precursors, glutathione — gate synaptic plasticity, myelination, and DNA/histone methylation in neurons and glia, linking metabolic state to neuroplastic capacity.

For depth (enzymes, pathways, pharmacology, and source URLs), follow the link above.