SmartDrugDiscovery.org Wiki

Welcome to the SmartDrugDiscovery.org research knowledge base — a continuously updated, AI-augmented wiki for drug discovery research from the SPARC lab at UAB.

Research Projects

• phgdh-research — PHGDH target research and serine biosynthesis
• PHGDH-Allosteric-RBD-Binder — Allosteric RBD binder discovery

Conference Proceedings

• Stanford Drug Discovery Symposium 2026 — 70-page interlinked wiki covering all 15 sessions, 40+ speakers, and cross-cutting themes in drug discovery science, Nobel-level research, AI, incretins, CAR-T, and federal policy

About

This wiki is the public-facing projection of an active Obsidian research vault. Use the graph view to explore connections, or search to find specific topics.

PLEASER Research Projects

• index — PHGDH RNA-Binding Domain Small Molecule Ranking (PLEASER)

• index — Disease to Target — Alzheimer’s GET Score Gene Prioritization (PLEASER)

• index — PHGDH ACT Domain — Lead Optimization for CNS-Penetrant AD Therapeutic (PLEASER)

• index — PHGDH RNA-Binding Domain Characterization (PLEASER)