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PHGDH ACT Domain — Lead Optimization for CNS-Penetrant AD Therapeutic — Wiki Index

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PHGDH ACT Domain — Lead Optimization for CNS-Penetrant AD Therapeutic — Research Wiki

Continuously updated by the PLEASER Sharer agent. Each cycle adds a new page.

A.G.E. Scores Dashboard

Rows = agents, columns = cycles. Cells show NIH score / composite score. NIH: 1–3 ✅ strong · 4–6 ⚠️ adequate · 7–9 🔴 weak

Agent \ Cycle12345678910111213141516
PLANNER0.67 ⚠️0.70 ✅0.69 ✅0.64 ⚠️0.63 ⚠️0.64 ⚠️0.64 ⚠️0.64 ⚠️0.64 ⚠️0.65 ⚠️0.66 ⚠️0.66 ⚠️0.66 ⚠️0.66 ⚠️0.65 ⚠️0.67 ⚠️
LEARNER0.70 ✅0.58 ⚠️0.51 ⚠️0.55 ⚠️0.50 ⚠️0.49 ⚠️0.49 ⚠️0.54 ⚠️0.55 ⚠️0.52 ⚠️0.53 ⚠️0.55 ⚠️0.59 ⚠️0.60 ⚠️0.62 ⚠️0.62 ⚠️
EXECUTOR0.66 ⚠️0.78 ✅0.71 ✅0.73 ✅0.71 ✅0.74 ✅0.74 ✅0.74 ✅0.72 ✅0.71 ✅0.74 ✅0.74 ✅0.74 ✅0.76 ✅0.75 ✅0.74 ✅
SHARER0.65 ⚠️0.73 ✅0.73 ✅0.70 ✅0.68 ⚠️0.70 ✅0.69 ✅0.65 ⚠️0.63 ⚠️0.64 ⚠️0.62 ⚠️0.64 ⚠️0.64 ⚠️0.63 ⚠️0.63 ⚠️0.63 ⚠️

Cycle Reports

17 items under this folder.