Amyloid-Beta (Aβ)

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At a glance

Aβ peptides are proteolytic fragments of APP processed by β- and γ-secretases. Aggregation drives AD pathology.

Where this comes up in the wiki

• Full article in PHGDH research
• Alzheimer’s Disease (SDDS 2026) — the A-beta paradox: lecanemab clears plaques but only slows decline by 27%; Südhof’s iPSC data shows A-beta 40 increases synapse formation