SGR-1505

A physics-discovered small molecule developed by Schrödinger. Presented by Karen Akinsanya at Session I.

Key Data

• Asset to clinic-ready in 10 months
• 100% response rate in Waldenström’s macroglobulinemia (MYD88 overexpression provides the genetic rationale)
• Broader lymphoma response is uneven — the team admits they don’t fully understand non-response

Significance

Demonstrates that when chemistry is the bottleneck, AI/physics-based design can radically compress timelines. Biology’s bottleneck is the next frontier.